If someone is going to win the Democratic nomination for President: You can lose states like Iowa, New Hampshire, Vermont... But states like South Carolina are critical. South Carolina represents the most diverse electorate thus far in the primary season. With the diversity of the Democratic base, it is difficult to see how Sanders has a path forward if he doesn't at least cut Clinton's South Carolina margin down to <10%. If he loses South Carolina by >25%, and goes on to lose Massachusetts and Minnesota or Colorado: He will essentially be completely eliminated.
On that note, the same is true on the Republican side. If Ted Cruz cannot win Texas (and win it by more an a couple points), he will have basically proven that Donald Trump is unstoppable in his quest for the nomination. If Cruz cannot win Texas, there is no reason to think Rubio can win Florida and Kasich can win Ohio.
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