CO-6: This is a seat currently held by Republican Representative Mike Coffman. This is a seat that became much more blue after redistricting. In 2008 the district went +7% for McCain and in 2012 the district went +5% for Obama. That being said, the district had been trending less and less red over the years prior to redistricting. The district went Bush +23% in 2000 and Bush +21% in 2004. The house seat here has never been held by a Democrat since being created in 1983. That being said, it is now a light blue seat and is a possible Democratic pickup. The pickup chances here would increase if Mike Coffman ran for the Senate rather than the house, but that is another story. Coffman won by 2% in 2012 (outpacing Romney by 7%) and 8.91% in 2014. Even with the incumbent, the race is more likely to be similar to 2012 than 2014.
Senate: Democratic Senior Senator Michael Bennet will be running for a second full term in the Senate. He won a tight race in 2010 against a lightweight opponent, Ken Buck. While Buck could try for a rematch, he is unlikely to get much love from the GOP after his 2010 performance. Mike Coffman has been talking about for this seat, but he may be better off staying in his house seat where the GOP would be likely to lose that seat should Coffman run for Senate. He would also be the party's best chance at picking up the Senate seat. The newly elected Cynthia Coffman (Rep. Coffman's wife and Colorado Attorney General) could also run for the seat, but she has yet to indicate any intention of running for it at this point.
The only polling for this race at this point is a March PPP poll that shows Bennet losing to Mike Coffman by 3%, but beat Cynthia Coffman by 8%. Other potential candidates here for the GOP nomination include State Senator Ellen Roberts, Representative Scott Tipton (CO-3), and State Treasurer Walker Stapleton. Walker Stapleton is the only one of the group elected to statewide office (outside of Cynthia Coffman) and his mother is a first cousin to former President George H.W. Bush (making him a second cousin to former President George W. Bush).
President: Here is where things start to get even more abstract. If you believe a recent Quinnipiac poll, Clinton has a MoE deficit to Paul, Rubio and Walker while sitting tied with Mike Huckabee and leading Bush, Christie, and Cruz in the MoE. PPP and the other more recent Quinnipiac polls show Clinton with mid to upper single digit leads over all GOP candidates most of the time. Once things settle down, this will likely be a state that goes for Clinton (like it did Obama) by mid to high single digits. The better Clinton does here, the better Democrats will do in the Senate race and Colorado's 6th Congressional District.